ELP-004
ELP-004 is a TRPC channel inhibitor and inhibtis TRPC channel-mediated Ca2+ entry. ELP-004 is an osteoclast inhibitor and inhibits osteoclast differentiation. ELP-004 inhibits basal Ca2+ and related NFATc1 translocation in inflammatory osteoclastogenesis. ELP-004 reduces bone erosion in a mouse model of rheumatoid arthritis[1][2].
Product Specifications
CAS Number
15533-81-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCC(N(C1=CC(Cl)=C(C=C1)Cl)C)=O
Molecular Formula
C10H11Cl2NO
Molecular Weight
232.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Ray S, et al. Targeting TRPC channels for control of arthritis-induced bone erosion. Sci Adv. 2025 Jan 17;11 (3) :eabm9843.|[2]McCall JL, et al. Preclinical evaluation of ELP-004 in mice. Pharmacol Res Perspect. 2024 Aug;12 (4) :e1230.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
516940 96 Tests
17-Hydroxyprogesterone (17-OHP) Instant BioAssayTM ELISA Kit (General)
Sign In for Pricing
View Details