(S) -ML188
(S) -ML188 is a SARS-CoV 3-chymotrypsin-like protease (3CLpro) inhibitor (IC50: 1.5 μM) . (S) -ML188 has antiviral activity with an EC50 value of 12.9 μM against SARS-CoV. (S) -ML188 inhibits the activity of 3CLpro via non-covalent binding and can be used in the study of SARS-CoV[1].
Product Specifications
CAS Number
1417700-12-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
SARS-CoV; Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CC(C)(NC([C@H](C1=CC=CN=C1)N(C2=CC=C(C(C)(C)C)C=C2)C(C3=CC=CO3)=O)=O)C
Molecular Formula
C26H31N3O3
Molecular Weight
433.54
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Turlington M, et al. Discovery of N- (benzo[1,2,3]triazol-1-yl) -N- (benzyl) acetamido) phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorg Med Chem Lett. 2013 Nov 15;23 (22) :6172-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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