MDH1/2-IN-1
MDH1/2-IN-1 is a MDH1/2 inhibitor (IC50: 1.07 nM and 1.06 nM respectively) . MDH1/2-IN-1 inhibits mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 demonstrates significant anti-tumor potential. MDH1/2-IN-1 provides a new direction for the development of drugs targeting cancer metabolism[1].
Product Specifications
CAS Number
2143473-95-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIF/HIF Prolyl-Hydroxylase; Malate Dehydrogenase (MDH) ; Mitochondrial Metabolism
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.53
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(NC(CCOC2=CC=C(C(C)(CC(C)(C)C)C)C=C2)=O)=CC=C1)OC
Molecular Formula
C25H33NO4
Molecular Weight
411.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Naik R, et al. Methyl 3- (3- (4- (2,4,4-Trimethylpentan-2-yl) phenoxy) -propanamido) benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism. J Med Chem. 2017 Oct 26;60 (20) :8631-8646.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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