FP802
FP802 is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology[1]. FP802 stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS) [2]. FP802 can be used for AD and ALS research[1][2].
Product Specifications
UNSPSC
12352005
Hazard Statement
H302-H314-H335
Target
IGluR; TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CCN(CC1=CC(Cl)=CC=C1)CCN
Molecular Formula
C11H17ClN2
Molecular Weight
212.72
Precautions
P260-P264-P270-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W611371/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[61694-81-3]
Available Sizes
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