MC-Val-Ala-NHS ester
MC-Val-Ala-NHS ester is a cleavable ADC linker with a malimide group and an NHS ester group. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide group is reactive toward thiol groups. MC is reactive with thiol moieties. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond.
Product Specifications
CAS Number
[1895916-22-9]
UNSPSC
12352203
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(ON2C(CCC2=O)=O)=O)=O)=O
Molecular Formula
C22H30N4O8
Molecular Weight
478.50
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
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