Coprostanone

Coprostanone (5β-cholestan-3-one) is an oxysterol and active metabolite of Cholesterol. Coprostanone induces apoptosis in primary dog gallbladder epithelial cells. Coprostanone is promising for research of colon cancers or adenomatous polyps[1][2].

Product Specifications

CAS Number

601-53-6

Product Name Alternative

5β-Cholestan-3-one

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Drug Metabolite

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.92

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](CC(CC4)=O)([H])CC3)C

Molecular Formula

C27H46O

Molecular Weight

386.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Seo DW, et al. Oxysterols from human bile induce apoptosis of canine gallbladder epithelial cells in monolayer culture. Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287 (6) :G1247-56.|[2]Reddy BS, et al. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer. 1977 Jun;39 (6) :2533-9.