Thiamine triphosphoric acid ester

Thiamine triphosphoric acid ester (TTP), a neuroactive compound, is a triphosphate derivative of the vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. Thiamine triphosphoric acid ester is transiently produced in response to amino acid starvation in E. coli, while constitutively producing at a low rate in mammalian cells. Thiamine triphosphoric acid ester can be synthesized by two different enzymes (AK1 in the cytosol and FoF1-ATP synthase in brain mitochondria) . Thiamine triphosphoric acid ester has a basic role in cell metabolism or cell signaling[1][2].

Product Specifications

CAS Number

[3475-65-8]

Product Name Alternative

Thiamine triphosphate

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Neurological Disease

Smiles

O=P(O)(OP(O)(OP([O-])(OCCC1=C(C)[N+](CC2=CN=C(C)N=C2N)=CS1)=O)=O)O

Molecular Formula

C12H19N4O10P3S

Molecular Weight

504.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Makarchikov AF, et al. Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cell Mol Life Sci. 2003 Jul;60 (7) :1477-88.|[2]Bettendorff L, et al. Thiamine triphosphate: a ubiquitous molecule in search of a physiological role. Metab Brain Dis. 2014 Dec;29 (4) :1069-82.