6-Phosphoglucono-δ-lactone

6-Phosphoglucono-δ-lactone (6-PGδL) is a reversal substrate of glucose-6-phosphate dehydrogenase (G6PD) . 6-Phosphoglucono-δ-lactone is an intermediate compound in the oxidative branch of the pentose phosphate pathway (PPP) . 6-Phosphoglucono-δ-lactone produced from D-glucose-6-phosphate by glucose-6-phosphate dehydrogenase (G6PDH) and is converted to 6-phosphoglutonate by lactonase. 6-Phosphoglucono-δ-lactone can be used for heart failure, type 2 diabetes and cancers research[1][2].

Product Specifications

CAS Number

[2641-81-8]

Product Name Alternative

6-PGδL; 6-Phosphonoglucono-D-lactone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; PDI

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Cardiovascular Disease

Purity

99.0

Smiles

O=P(O)(O)OC[C@@H]1[C@H]([C@@H]([C@H](C(O1)=O)O)O)O

Molecular Formula

C6H11O9P

Molecular Weight

258.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Preuss J, et al. Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. J Biomol Screen. 2013 Mar;18 (3) :286-97.