Mono (2-ethyl-5-hydroxyhexyl) terephthalate

Mono (2-ethyl-5-hydroxyhexyl) terephthalate (MEHHTP), a hydroxyl metabolite of the phthalate alternative Di-2-ethylhexyl terephthalate (DEHTP), is a liver X receptor α (LXRα) agonist with a binding energy of -7.41 kcal/mol. Mono (2-ethyl-5-hydroxyhexyl) terephthalate upregulates LXRα downstream targets such as SREBP-1c and FASN and increases lipogenic enzyme activity in hepatocytes, and elevating triglyceride (TG) levels. Mono (2-ethyl-5-hydroxyhexyl) terephthalate is promising for research of nonalcoholic fatty liver disease (NAFLD) [1].

Product Specifications

CAS Number

[1684398-38-6]

Product Name Alternative

MEHHTP

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

98.27

Smiles

O=C(C1=CC=C(C(O)=O)C=C1)OCC(CC)CCC(O)C

Molecular Formula

C16H22O5

Molecular Weight

294.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Li J, et al. Association of Di (2-ethylhexyl) Terephthalate and Its Metabolites with Nonalcoholic Fatty Liver Disease: An Epidemiology and Toxicology Study. Environ Sci Technol. 2024 May 14;58 (19) :8182-8193.