Benzylhydrochlorothiazide

Benzylhydrochlorothiazide is an orally active thiazide diuretic. Benzylhydrochlorothiazide acts on the distal convoluted tubules of the kidneys, inhibiting the reabsorption of sodium chloride, thereby increasing urine output and reducing the body's fluid volume. Benzylhydrochlorothiazide has phototoxicity and a potential risk of skin reactions. Benzylhydrochlorothiazide can cause cell death when exposed to UVA radiation. Benzylhydrochlorothiazide is used in research on hypertension and edema[1].

Product Specifications

CAS Number

[1824-50-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Smiles

O=S(C1=C(Cl)C=C(C2=C1)NC(CC3=CC=CC=C3)NS2(=O)=O)(N)=O

Molecular Formula

C14H14ClN3O4S2

Molecular Weight

387.86

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Inamoto N, et al. Porokeratosis of Mibelli: benzylhydrochlorothiazide-induced new lesions accompanied by eosinophilic spongiosis. J Am Acad Dermatol. 1984 Aug;11 (2 Pt 2) :357-61. |[2]Selvaag E, et al. Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics. J Photochem Photobiol B. 1997 Mar;38 (1) :88-93.