Cholic acid 3-O-glucuronide (disodium)

Cholic acid 3-O-glucuronide (OCA-3-glucuronide) disodium is a farnesoid X receptor (FXR) agonist with an EC50 value of 91.5 μM. Cholic acid 3-O-glucuronide is promising for research of bile acid metabolism and detoxification[1][2].

Product Specifications

CAS Number

[59274-69-0]

Product Name Alternative

OCA-3-glucuronide (disodium)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

FXR

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(O[Na])=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O[Na])=O)([H])C1)C)O)C

Molecular Formula

C30H46Na2O11

Molecular Weight

628.66

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Mostarda S, et al. Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification. Eur J Med Chem. 2018 Jan 20;144:349-358.|[2]Mach S, et al. Metabolism of obeticholic acid in brown bullhead (Ameiurus nebulosus) . Environ Sci Pollut Res Int. 2019 Jul;26 (20) :20316-20324.