N-Methylated pomalidomide
N-methylated pomalidomide (Pomalidomide-methyl), a derivative of Pomalidomide , is a cereblon (CRBN) ligand. N-methylated pomalidomide is unable to recruit CRBN that can be used as a negative control for Pomalidomide. N-methylated pomalidomide can be used to synthesize PROTAC[1].
Product Specifications
CAS Number
1352827-50-9
Product Name Alternative
Pomalidomide-methyl
UNSPSC
12352005
Hazard Statement
H302, H312, H332, H361
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
97.86
Smiles
O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(N)=CC=C2
Molecular Formula
C14H13N3O4
Molecular Weight
287.27
Precautions
H302, H312, H332, H361
References & Citations
[1]Yokoo H, et al. Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett. 2021 Jan 14;12 (2) :236-241.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Histone H4 (mono methyl K20) (H4F2, H4FN, HIST1H4, HIST2H4, HISTH4H4, Methyl Histone H4, Methylated Histone H4)
FGFR1 Recombinant Antibody, AbBy Fluor™ 555 Conjugated