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Fructose-phenylalanine

Fructose-phenylalanine (Fru-Phe) is a non-competitive angiotensin-converting enzyme (ACE) inhibitor (IC50 =0.19 mM) with antioxidant activities. Fructose-phenylalanine forms a stable complex with Zn2+ ions at the ACE active site, blocking the conversion of angiotensin I to II and thereby lowering blood pressure. Fructose-phenylalanine is promising for research of cardiovascular diseases[1][2].

Product Specifications

CAS Number

31105-03-0

Product Name Alternative

Fru-Phe

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Angiotensin-converting Enzyme (ACE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

OC[C@@H](O)[C@@H](O)[C@H](O)C(CN[C@H](C(O)=O)CC1=CC=CC=C1)=O

Molecular Formula

C15H21NO7

Molecular Weight

327.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Johnson GH, et al. Nutritional implications of the Maillard reaction: the availability of fructose-phenylalanine to the chick. J Nutr. 1977 Sep;107 (9) :1659-64.|[2]Jiahao Yu, et al. Potential contribution of Amadori compounds to antioxidant and angiotensin I converting enzyme inhibitory activities of raw and black garlic. LWT, Volume 129, 2020, 109553, ISSN 0023-6438

Shipping Conditions

Room temperature

Scientific Category

Reference compound2

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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