Nε- (Carboxyethyl) lysine

Nε- (Carboxyethyl) lysine is an advanced glycation end product (AGE) . Nε- (Carboxyethyl) lysine causes cross-linking between proteins, affects the structure and function of proteins, and leads to protein denaturation. Nε- (Carboxyethyl) lysine binds to RAGE receptors, affects cell signaling, regulates processes such as inflammatory response, cell proliferation and apoptosis. Nε- (Carboxyethyl) lysine affects glutamate transporter, reduces glutamate uptake and S100B protein secretion, affects neurotransmission in the nervous system, and exhibits diabetic-related neurotoxicity[1][2].

Product Specifications

CAS Number

[5746-03-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

EAAT

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.9

Smiles

N[C@@H](CCCCNC(C(O)=O)C)C(O)=O

Molecular Formula

C9H18N2O4

Molecular Weight

218.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Ahmed MU, et al., N-epsilon- (carboxyethyl) lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. Biochem J. 1997 Jun 1;324 (Pt 2) (Pt 2) :565-70. |[2]Hansen F, et al., Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation. Amino Acids. 2016 Feb;48 (2) :375-85.