1,1′-Ethylidenebis[L-tryptophan]

1,1′-Ethylidenebis[L-tryptophan] is an impurity in the synthesis of L-tryptophan. 1,1′-Ethylidenebis[L-tryptophan] promotes the proliferation of eosinophilic leukemia cells, induces the release of eosinophil cationic protein from eosinophils, and stimulates T cells to produce IL-5. 1,1′-Ethylidenebis[L-tryptophan] (40 µg/kg) can induce fascia thickening, mast cell infiltration, and fibrosis in adipose and subcutaneous muscle tissues in mice. 1,1′-Ethylidenebis[L-tryptophan] can be used in immunology and inflammation research[1][2][3].

Product Specifications

CAS Number

[132685-02-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Interleukin Related

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

CC(N1C2=CC=CC=C2C(C[C@H](N)C(O)=O)=C1)N3C4=CC=CC=C4C(C[C@H](N)C(O)=O)=C3

Molecular Formula

C24H26N4O4

Molecular Weight

434.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yamaoka KA, et al. 1,1'-Ethylidenebis (tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant. J Clin Immunol. 1994 Jan;14 (1) :50-60.|[2]Trucksess MW. Separation and isolation of trace impurities in L-tryptophan by high-performance liquid chromatography. J Chromatogr. 1993 Feb 5;630 (1-2) :147-50.|[3]Love LA, et al. Pathological and immunological effects of ingesting L-tryptophan and 1,1'-ethylidenebis (L-tryptophan) in Lewis rats. J Clin Invest. 1993 Mar;91 (3) :804-11.