STX107
STX107 is a metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulator (NAM) with a pKi of 8.32. STX107 inhibits glutamate-induced Ca2+ mobilization, IP1 accumulation, and ERK1/2 phosphorylation. STX107 also inhibits glutamate-induced mGlu5 internalization[1].
Product Specifications
CAS Number
935685-90-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
ERK; mGluR
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
N#CC1=CC(F)=CC(C2=NC=C(C=C2)C#CC3=CSC(C)=N3)=C1
Molecular Formula
C18H10FN3S
Molecular Weight
319.36
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Arsova A, et al. Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5. Mol Pharmacol. 2020 Jul;98 (1) :49-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
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