1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (1,2,3,6,7,8-HxCDD) is an AHR agonist, with reported gene assay EC50 values of 5.4 nM at 4 hours and 9.3 nM at 8 hours. 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (at doses of 0.5 and 2 µg/kg) has been shown to reduce the production of antibodies against sheep red blood cells in mice. 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin is an environmental pollutant, found in animal feed and detected in the air near municipal waste incinerators[1].

Product Specifications

CAS Number

[57653-85-7]

Product Name Alternative

1,2,3,6,7,8-HxCDD

UNSPSC

12352005

Hazard Statement

H301-H319-H413

Target

Aryl Hydrocarbon Receptor

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

C1=C2C(=C(C(=C1Cl)Cl)Cl)OC3=CC(=C(C(=C3O2)Cl)Cl)Cl

Molecular Formula

C12H2Cl6O2

Molecular Weight

390.86

Precautions

P264-P270-P273-P280-P305+P351+P338-P330-P405-P501

References & Citations

[1]Hu SW, et al. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere. 2004 Apr;55 (4) :611-20. |[2]Pajurek M, et al. Feed as a source of dioxins and PCBs. Chemosphere. 2022 Dec;308 (Pt 1) :136243.|[3]Xu T, et al. A rapid and reagent-free bioassay for the detection of dioxin-like compounds and other aryl hydrocarbon receptor (AhR) agonists using autobioluminescent yeast. Anal Bioanal Chem. 2018 Feb;410 (4) :1247-1256. |[4]Holsapple MP, et al. Suppression of humoral antibody production by exposure to 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin. J Pharmacol Exp Ther. 1984 Dec;231 (3) :518-26.