SMARCA2-IN-10

SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor (IC50=17.676 μM) . SMARCA2-IN-10 induces cell death in SMARCA4-deficient tumors. SMARCA2-IN-10 is promising for research of SMARCA4-mutant non-small cell lung cancer, small cell ovarian carcinoma, and melanoma[1].

Product Specifications

CAS Number

[82131-85-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Epigenetic Reader Domain

Related Pathways

Epigenetics

Field of Research

Cancer

Smiles

O=C(C1=CC=CC=C1C(O)=O)NC2=CC=C(OC3=CC=C(NC(C4=CC=CC=C4C(O)=O)=O)C=C3)C=C2

Molecular Formula

C28H20N2O7

Molecular Weight

496.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Zhu J, et al. Discovery of Novel Selective Inhibitors of SMARCA2 ATPase Domain by Virtual Screening and Biological Evaluation. ACS Med Chem Lett. 2025 Sep 15;16 (10) :2032-2040.