SMARCA2-IN-10
SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor (IC50=17.676 μM) . SMARCA2-IN-10 induces cell death in SMARCA4-deficient tumors. SMARCA2-IN-10 is promising for research of SMARCA4-mutant non-small cell lung cancer, small cell ovarian carcinoma, and melanoma[1].
Product Specifications
CAS Number
82131-85-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Epigenetic Reader Domain
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C(C1=CC=CC=C1C(O)=O)NC2=CC=C(OC3=CC=C(NC(C4=CC=CC=C4C(O)=O)=O)C=C3)C=C2
Molecular Formula
C28H20N2O7
Molecular Weight
496.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zhu J, et al. Discovery of Novel Selective Inhibitors of SMARCA2 ATPase Domain by Virtual Screening and Biological Evaluation. ACS Med Chem Lett. 2025 Sep 15;16 (10) :2032-2040.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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