Pyrraline

Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD (P) H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers[1][2].

Product Specifications

CAS Number

[74509-14-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite; Keap1-Nrf2; NF-κB

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Metabolic Disease

Smiles

C1=C(N(C(=C1)C=O)CCCC[C@@H](C(=O)O)N)CO

Molecular Formula

C12H18N2O4

Molecular Weight

254.28

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hu C, et al. Untargeted metabolite profiling of serum in rats exposed to pyrraline. Food Sci Biotechnol. 2023 Jan 26;32 (11) :1541-1549.|[2]Raupbach J, et al. The Effect of Free and Protein-Bound Maillard Reaction Products N-ε-Carboxymethyllysine, N-ε-Fructosyllysine, and Pyrraline on Nrf2 and NFκB in HCT 116 Cells. Mol Nutr Food Res. 2023 Sep;67 (18) :e2300137.