5'-O-DMT-N2-Ibu-2'-OMe-G

5'-O-DMT-N2-Ibu-2'-OMe-G is a crucial intermediate for the synthesis of antisense oligonucleotides. 5'-O-DMT-N2-Ibu-2'-OMe-G is involved in constructing antisense oligonucleotides with specific sequences, which can bind complementarily to the targeted mRNA. 5'-O-DMT-N2-Ibu-2'-OMe-G blocks the translation process of mRNA, thereby inhibiting the expression of specific proteins and playing a role in regulating gene expression. 5'-O-DMT-N2-Ibu-2'-OMe-G is promising for research of genetic diseases and tumors[1].

Product Specifications

CAS Number

[251647-50-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.0

Smiles

O=C1C2=C(N([C@H]3[C@H](OCCOC)[C@H](O)[C@@H](COC(C4=CC=C(OC)C=C4)(C5=CC=CC=C5)C6=CC=C(OC)C=C6)O3)C=N2)N=C(NC(C(C)C)=O)N1

Molecular Formula

C38H43N5O9

Molecular Weight

713.78

Precautions

H302, H315, H319, H335

References & Citations

[1]Taj SA, et al. Process development for the synthesis of 5'-O- (4,4'-dimethoxytrityl) -N2-isobutyryl-2'-O- (2-methoxyethyl) -guanosine--a potential precursor for the second generation antisense oligonucleotides: an improved process for the preparation of 2'-O-alkyl-2,6-diaminopurine riboside. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22 (5-8) :1327-30.