GL-522
GL-522 (4-Sulfocalix[8]arene) is a Aβ42 inhibitor. GL-522 bind to Aβ42 through nonspecific and multipoint hydrophobic interactions with a Kd of 276 μM. GL-522 effectively inhibits Aβ42 fibrillation and reduces amyloid cytotoxicity. GL-522 can be used for Alzheimer's disease research[1].
Product Specifications
Product Name Alternative
4-Sulfocalix[8]arene
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=S(O)(C1=CC(CC2=CC(S(=O)(O)=O)=CC(CC3=CC(S(=O)(O)=O)=CC(CC4=CC(S(=O)(O)=O)=CC(CC5=C(O)C(CC6=C(O)C(CC7=C(O)C(CC8=C(O)C(C9)=CC(S(=O)(O)=O)=C8)=CC(S(=O)(O)=O)=C7)=CC(S(=O)(O)=O)=C6)=CC(S(=O)(O)=O)=C5)=C4O)=C3O)=C2O)=C(O)C9=C1)=O
Molecular Formula
C56H48O32S8
Molecular Weight
1489.48
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Wang Z, et al. para-Sulfonatocalix[n]arenes Inhibit Amyloid β-Peptide Fibrillation and Reduce Amyloid Cytotoxicity. Chem Asian J. 2017 Feb 1;12 (3) :341-346.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W440556/
Scientific Category
Reference compound2
Clinical Information
No Development Reported
CAS Number
[137407-62-6]
Curated Selection
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