4-Sulfocalix[4]arene

4-Sulfocalix[4]arene (para-Sulfonatocalix[n]arene) is a amyloid-beta 42 binder with a Kd of 5.39 M. 4-Sulfocalix[4]arene can inhibit amyloid β-peptide fibrillation and reduce amyloid cytotoxicity[1].

Product Specifications

CAS Number

[112269-92-8]

Product Name Alternative

Para-Sulfonatocalix[n]arene

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Amyloid-β

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Purity

94.0

Smiles

O=S(O)(C1=CC(CC2=CC(S(=O)(O)=O)=CC(CC3=C(O)C(CC4=C(O)C(C5)=CC(S(=O)(O)=O)=C4)=CC(S(=O)(O)=O)=C3)=C2O)=C(O)C5=C1)=O

Molecular Formula

C28H24O16S4

Molecular Weight

744.74

Precautions

H315, H319, H335

References & Citations

[1]Wang Z, et al. para-Sulfonatocalix[n]arenes Inhibit Amyloid β-Peptide Fibrillation and Reduce Amyloid Cytotoxicity. Chem Asian J. 2017 Feb 1;12 (3) :341-346.