4-Sulfocalix[4]arene
4-Sulfocalix[4]arene (para-Sulfonatocalix[n]arene) is a amyloid-beta 42 binder with a Kd of 5.39 M. 4-Sulfocalix[4]arene can inhibit amyloid β-peptide fibrillation and reduce amyloid cytotoxicity[1].
Product Specifications
CAS Number
112269-92-8
Product Name Alternative
Para-Sulfonatocalix[n]arene
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Purity
94.0
Smiles
O=S(O)(C1=CC(CC2=CC(S(=O)(O)=O)=CC(CC3=C(O)C(CC4=C(O)C(C5)=CC(S(=O)(O)=O)=C4)=CC(S(=O)(O)=O)=C3)=C2O)=C(O)C5=C1)=O
Molecular Formula
C28H24O16S4
Molecular Weight
744.74
Precautions
H315, H319, H335
References & Citations
[1]Wang Z, et al. para-Sulfonatocalix[n]arenes Inhibit Amyloid β-Peptide Fibrillation and Reduce Amyloid Cytotoxicity. Chem Asian J. 2017 Feb 1;12 (3) :341-346.
Shipping Conditions
Room Temperature
Storage Conditions
RT, stored under nitrogen
Scientific Category
Reference compound2
Clinical Information
No Development Reported
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