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V-161

V-161 is the orally active inhibitor for Na+-V-ATPase with an IC50 of 144 nM. V-161 inhibits Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline condition with MIC of 4 µg/mL and 4 µg/mL. V-161 inhibits colonization of VRE in mouse small intestine[1].

Product Specifications

CAS Number

69570-95-2

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bacterial; Na+/K+ ATPase

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

CC1=CC2=C(C=C1)N=C(N2)C3=CC=C(C=C3)N(C)C

Molecular Formula

C16H17N3

Molecular Weight

251.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Suzuki K, et al., Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure. Nat Struct Mol Biol. 2024 Nov 21.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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