24,25-Epoxycholesterol
24,25-Epoxycholesterol is an oxysterol agonist of the liver X receptor that can inhibit the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in liver cells. 24,25-Epoxycholesterol regulates cholesterol metabolism in the liver[1].
Product Specifications
CAS Number
[72542-49-5]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
HMG-CoA Reductase (HMGCR) ; LXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Purity
99.80
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC3C(C)(O3)C)([H])[C@@]4([H])[C@@](CC1)([H])[C@@]5(C(C[C@H](CC5)O)=CC4)C
Molecular Formula
C27H44O2
Molecular Weight
400.64
Precautions
H302, H315, H319, H335
References & Citations
[1]Andrew J Brown, et al. 24 (S),25-epoxycholesterol: a messenger for cholesterol homeostasis. Int J Biochem Cell Biol. 2009 Apr;41 (4) :744-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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