ICR-191 (dihydrochloride)
ICR-191 enhances Cisplatin - DNA binding and sensitizes cells to cisplatin. ICR-191 induces a significant increase in the expression of phosphorylated H2AX (γH2AX), particularly in DNA-replicating cells. ICR-191 can be used for the study of leukemia[1][2].
Product Specifications
CAS Number
17070-45-0
UNSPSC
12352005
Hazard Statement
H300+H310+H330, H350
Target
DNA/RNA Synthesis; Fluorescent Dye
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Purity
95.0
Smiles
ClC1=CC2=NC(C=CC(OC)=C3)=C3C(NCCCNCCCl)=C2C=C1.Cl.Cl
Molecular Formula
C19H23Cl4N3O
Molecular Weight
451.22
Precautions
H300+H310+H330, H350
References & Citations
[1]Shao C, et al. Pt-seq unveils the genomic binding pattern of platinum-based drugs. Sci Adv. 2025 Oct 31;11 (44) :eadx6809.|[2]Pietrzak M, et al. Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin. Biophys Chem. 2008 Jun;135 (1-3) :69-75.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound2
Clinical Information
No Development Reported
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