ICR-191 (dihydrochloride)

ICR-191 enhances Cisplatin (HY-17394) - DNA binding and sensitizes cells to cisplatin. ICR-191 induces a significant increase in the expression of phosphorylated H2AX (γH2AX), particularly in DNA-replicating cells. ICR-191 can be used for the study of leukemia[1][2].

Product Specifications

CAS Number

[17070-45-0]

UNSPSC

12352005

Hazard Statement

H300+H310+H330, H350

Target

DNA/RNA Synthesis; Fluorescent Dye

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Purity

95.0

Smiles

ClC1=CC2=NC(C=CC(OC)=C3)=C3C(NCCCNCCCl)=C2C=C1.Cl.Cl

Molecular Formula

C19H23Cl4N3O

Molecular Weight

451.22

Precautions

H300+H310+H330, H350

References & Citations

[1]Shao C, et al. Pt-seq unveils the genomic binding pattern of platinum-based drugs. Sci Adv. 2025 Oct 31;11 (44) :eadx6809.|[2]Pietrzak M, et al. Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin. Biophys Chem. 2008 Jun;135 (1-3) :69-75.