Probenecid (sodium)
Probenecid sodium is the sodium salt of Probenecid. Probenecid is an effective selective transient receptor potential vanilloid 2 (TRPV2) agonist. Probenecid also inhibits the pannexin 1 channel[1][2][3][4].
Product Specifications
CAS Number
23795-03-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; HIV; TRP Channel
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Infection
Concentration
10mM
Purity
99.37
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CC=C(S(=O)(N(CCC)CCC)=O)C=C1)O[Na]
Molecular Formula
C13H18NNaO4S
Molecular Weight
307.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53 (1) :134-44.|[2]Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57 (4) :760-8.|[3]Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6 (5) :e20123.|[4]Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295 (3) :C761-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
TRPV2
Available Sizes
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