Probenecid (sodium)

Probenecid sodium is the sodium salt of Probenecid. Probenecid is an effective selective transient receptor potential vanilloid 2 (TRPV2) agonist. Probenecid also inhibits the pannexin 1 channel[1][2][3][4].

Product Specifications

CAS Number

[23795-03-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; HIV; TRP Channel

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Infection

Concentration

10mM

Purity

99.37

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=CC=C(S(=O)(N(CCC)CCC)=O)C=C1)O[Na]

Molecular Formula

C13H18NNaO4S

Molecular Weight

307.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53 (1) :134-44.|[2]Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57 (4) :760-8.|[3]Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6 (5) :e20123.|[4]Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295 (3) :C761-7.