12-Ketochenodeoxycholic acid (Standard)

Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1][2][3][4].

Product Specifications

CAS Number

[2458-08-4]

UNSPSC

12352211

Hazard Statement

H315-H319

Target

Autophagy; Reference Standards

Related Pathways

Autophagy; Others

Field of Research

Metabolic Disease

Smiles

C[C@H](CCC(O)=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O

Molecular Formula

C24H38O5

Molecular Weight

406.56

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Sawada, H. et al. Microbial production of chenodeoxycholic acid precursor, 12-ketochenodeoxycholic acid, from dehydrocholic acid. European Journal of Applied Microbiology and Biotechnology, 10 (1–2), 107–112.