D-myo-Inositol-4-phosphate (monoammonium)

D-myo-Inositol-4-phosphate monoammonium is a metabolite of D-myo-Inositol 1,4,5-trisphosphate. D-myo-Inositol 1,4,5-trisphosphate, a second messenger, elicits Ca2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2) [1][2][3].

Product Specifications

UNSPSC

12352211

Target

Calcium Channel; Drug Metabolite

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O[C@@H]1[C@H]([C@@H]([C@H]([C@H]([C@H]1O)O)O)OP([O-])(O)=O)O.[NH4+]

Molecular Formula

C6H16NO9P

Molecular Weight

277.17

References & Citations

[1]Cifuentes ME, et al. D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes. J Biol Chem. 1994 Jan 21;269 (3) :1945-8. |[2]Gou DM, et al. D-myo-inositol 1,4,5-trisphosphate analogues as useful tools in biochemical studies of intracellular calcium mobilization. Bioorg Med Chem. 1994 Jan;2 (1) :7-13. |[3]Foster PS, et al. The metabolism of D-myo-inositol 1,4,5-trisphosphate and D-myo-inositol 1,3,4,5-tetrakisphosphate by porcine skeletal muscle. Eur J Biochem. 1994 Jun 15;222 (3) :955-64.