3-Hydroxyvalproic acid

3-Hydroxyvalproic acid (3-Hydroxy VPA) is a metabolite of valproic acid. 3-Hydroxyvalproic acid is a weak inhibitor of enzymes related to the mitochondrial β-oxidation pathway. 3-Hydroxyvalproic acid is promising for research of diseases related to abnormal valproic acid metabolism[1][2][3].

Product Specifications

CAS Number

[58888-84-9]

Product Name Alternative

3-Hydroxy VPA

UNSPSC

12352211

Hazard Statement

H302-H312-H332

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

CCC(O)C(CCC)C(O)=O

Molecular Formula

C8H16O3

Molecular Weight

160.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Heinemeyer G, et al. Oxidation and glucuronidation of valproic acid in male rats--influence of phenobarbital, 3-methylcholanthrene, beta-naphthoflavone and clofibrate. Biochem Pharmacol. 1985 Jan 1;34 (1) :133-9.|[2]Prickett KS, et al. Metabolism of valproic acid by hepatic microsomal cytochrome P-450. Biochem Biophys Res Commun. 1984 Aug 16;122 (3) :1166-73.|[3]Bello-Ramírez AM, et al. Do structural properties explain the anticonvulsant activity of valproate metabolites? A QSAR analysis. Epilepsia. 2002 May;43 (5) :475-81.