2'-Deoxyuridine 5'-monophosphate

2'-Deoxyuridine 5'-monophosphate (dUMP) is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS) . dTMP is a nucleotide required for DNA synthesis[1].

Product Specifications

CAS Number

[964-26-1]

Product Name Alternative

DUMP

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Smiles

O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O)(O)=O

Molecular Formula

C9H13N2O8P

Molecular Weight

308.18

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP) -binding Tyr-261. Biochemistry. 2006 Jun 20;45 (24) :7415-28.|[2]Skouloubris S, et al. Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones. Open Biol. 2015 Jun;5 (6) :150015.