C1s-IN-1 (trihydrochloride)
C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM[1].
Product Specifications
CAS Number
[1376162-36-5]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Complement System
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
N=C(C1=CN=C(N2CCN(CC2)C3=CC=CC=C3)C=C1)N.Cl.Cl.Cl
Molecular Formula
C16H22Cl3N5
Molecular Weight
390.74
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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