C1s-IN-1 (trihydrochloride)

C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM[1].

Product Specifications

CAS Number

[1376162-36-5]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Complement System

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

N=C(C1=CN=C(N2CCN(CC2)C3=CC=CC=C3)C=C1)N.Cl.Cl.Cl

Molecular Formula

C16H22Cl3N5

Molecular Weight

390.74

Precautions

H302, H312, H332

References & Citations

[1]Xu X, et al., Inhibition of the C1s Protease and the Classical Complement Pathway by 6- (4-Phenylpiperazin-1-yl) Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol. 2024 Feb 15;212 (4) :689-701.