Gonyautoxin III
Gonyautoxin III (GTX-III) is a paralytic shellfish poisoning toxin. Gonyautoxin III can block of the voltage-gated sodium channels at axonal level with an IC50 of 14.9 nM, impeding nerve impulse propagation. Gonyautoxin III has killing activity against mouse neuroblastoma cells. Gonyautoxin III can be used for the researches of cancer and neurological disease[1][2].
Product Specifications
CAS Number
60537-65-7
Product Name Alternative
GTX-III
UNSPSC
12352005
Hazard Statement
H300+H310
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer; Neurological Disease
Smiles
OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2C[C@@H]1OS(=O)(O)=O)N)COC(N)=O)O
Molecular Formula
C10H17N7O8S
Molecular Weight
395.35
Precautions
P262-P264-P270-P280-P302+P352-P330-P361+P364-P405-P501
References & Citations
[1]Jellett JF, et al. Toxicological evaluation of saxitoxin, neosaxitoxin, gonyautoxin II, gonyautoxin II plus III and decarbamoylsaxitoxin with the mouse neuroblastoma cell bioassay. Toxicol In Vitro. 1995 Feb;9 (1) :57-65.|[2]Walker JR, et al. Divergent Synthesis of Natural Derivatives of (+) -Saxitoxin Including 11-Saxitoxinethanoic Acid. Angew Chem Int Ed Engl. 2019 Feb 4;58 (6) :1689-1693.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
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