11-Ketoprogesterone
11-Ketoprogesterone (11KP4) is the substrate for CYP17A1 and 11β-HSD2 that could be metabolized to 21-deoxycortisone (21dE) and 21-deoxycortisol (21dF) with glucocorticoid activity[1].
Product Specifications
CAS Number
[516-15-4]
Product Name Alternative
11KP4
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
11β-HSD; Cytochrome P450
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.44
Smiles
C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](CC3=O)([C@H](CC4)C(C)=O)C
Molecular Formula
C21H28O3
Molecular Weight
328.45
Precautions
H302, H315, H319, H335
References & Citations
[1]van Rooyen D, et al., CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. J Steroid Biochem Mol Biol. 2020 May;199:105614.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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