11-Ketoprogesterone

11-Ketoprogesterone (11KP4) is the substrate for CYP17A1 and 11β-HSD2 that could be metabolized to 21-deoxycortisone (21dE) and 21-deoxycortisol (21dF) with glucocorticoid activity[1].

Product Specifications

CAS Number

[516-15-4]

Product Name Alternative

11KP4

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

11β-HSD; Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.44

Smiles

C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](CC3=O)([C@H](CC4)C(C)=O)C

Molecular Formula

C21H28O3

Molecular Weight

328.45

Precautions

H302, H315, H319, H335

References & Citations

[1]van Rooyen D, et al., CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. J Steroid Biochem Mol Biol. 2020 May;199:105614.