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GCN2 activator-1

GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD) [1].

Product Specifications

CAS Number

315705-10-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Eukaryotic Initiation Factor (eIF) ; Pyruvate Kinase

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Purity

99.69

Solubility

DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC(C)=C(C2=CSC(NC3=NC=CC=N3)=N2)S1

Molecular Formula

C11H10N6S2

Molecular Weight

290.37

Precautions

H302, H315, H319, H335

References & Citations

[1]JiaYi Zhu, et al. A GCN1-independent activator of the kinase GCN2. bioRxiv 2025.06.29.662197

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound2

Clinical Information

No Development Reported

Isoform

EIF2

Available Sizes

Frequently Asked Questions

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