GCN2 activator-1
GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD) [1].
Product Specifications
CAS Number
[315705-10-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Eukaryotic Initiation Factor (eIF) ; Pyruvate Kinase
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Purity
99.69
Solubility
DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC(C)=C(C2=CSC(NC3=NC=CC=N3)=N2)S1
Molecular Formula
C11H10N6S2
Molecular Weight
290.37
Precautions
H302, H315, H319, H335
References & Citations
[1]JiaYi Zhu, et al. A GCN1-independent activator of the kinase GCN2. bioRxiv 2025.06.29.662197
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
EIF2
Available Sizes
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E2F1, Phosphorylated (Ser337) (Transcription Factor E2F1, E2F-1, Retinoblastoma Binding Protein 3, RBBP-3, PRB-binding Protein E2F-1, PBR3, Retinoblastoma-associated Protein 1, RBAP-1, RBBP3) (MaxLight 490)
