ROCK-IN-11
ROCK-IN-11 (example 94) is a potent inhibitor of ROCK1 and ROCK2, with the IC50 of ≤ 5μM. ROCK-IN-11 plays an important role in cancer research[1].
Product Specifications
CAS Number
445267-51-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=C(C(=CC(=C1)NC(=O)C2=C(C3=C(N=C(C=C3)C4=CC=NC=C4)S2)N)OC)OC
Molecular Formula
C22H20N4O4S
Molecular Weight
436.48
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Mehmet Kahraman, et al. Benzothiophene derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as inhibitors of Rho kinase. World Intellectual Property Organization, WO2008011560 A2 2008-01-24
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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