RSK2-IN-4
RSK2-IN-4 (Compound 10) is a RSK2 inhibitor, with an inhibition rate of 13.73% on RSK2 activity at 10 μM. RSK2-IN-4 binds to the ATP-binding site of RSK2 in the NTKD (N-terminal kinase domain), with the electron-donating group at the 4-position of the phenyl ring being the key determinant for its inhibitory activity [1].
Product Specifications
CAS Number
62001-32-5
UNSPSC
12352005
Hazard Statement
H302-H314
Target
Ribosomal S6 Kinase (RSK)
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer; Inflammation/Immunology
Smiles
ClC1=CC=C(NCN2N=NC3=C2C=CC=C3)C=C1
Molecular Formula
C13H11ClN4
Molecular Weight
258.71
Precautions
P260-P264-P270-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P330-P363-P405-P501
References & Citations
[1]Yuan J, et al. Triazole and benzotriazole derivatives as novel inhibitors for p90 ribosomal S6 protein kinase 2: synthesis, molecular docking and SAR analysis[J]. Chinese Journal of Chemistry, 2013, 31 (9) : 1192-1198.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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