4-Acetylaminoantipyrine-d3

4-Acetylaminoantipyrine-d3 is the deuterium labeled 4-Acetylaminoantipyrine (HY-W268542) . 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171) . 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX) [1]. 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD[2]. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation[3].

Product Specifications

CAS Number

[342821-66-3]

UNSPSC

12352005

Target

COX; Isotope-Labeled Compounds; PGE synthase; SOD

Related Pathways

Immunology/Inflammation; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1N(C2=CC=CC=C2)N(C(C)=C1NC(C([2H])([2H])[2H])=O)C

Molecular Formula

C13H12D3N3O2

Molecular Weight

248.30

References & Citations

[1]Berno CR, et al. Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24. |[2]Teng Y, et al. Insights into potentially toxic effects of 4-aminoantipyrine on the antioxidant enzyme copper-zinc superoxide dismutase. J Hazard Mater. 2013 Nov 15;262:318-24.|[3]Teng Y, et al. The interaction between 4-aminoantipyrine and bovine serum albumin: multiple spectroscopic and molecular docking investigations. J Hazard Mater. 2011 Jun.