PSF-IN-1

PSF-IN-1 (Compound No.10-3) is a RNA-binding protein (PSF) inhibitor and can effectively inhibit the PSF-RNA interaction (IC50: 2.2 pM) . PSF-IN-1 can increase histone acetylation, inhibit tumor cell proliferation and induce apoptosis. PSF-IN-1 has antitumor activity[1].

Product Specifications

CAS Number

[370582-94-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

COC1=CC=C(C=C1)C2=CC(=O)OC3=C2C=CC(=C3O)O

Molecular Formula

C16H12O5

Molecular Weight

284.26

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Takayama KI, et al. Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth. Cancer Res. 2021 Jul 1;81 (13) :3495-3508.