MAO-B-IN-46
MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM) . MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM) . MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance[1][2].
Product Specifications
CAS Number
27052-20-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Amylases; Monoamine Oxidase
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Smiles
C1=CC=C2C(=C1)C=C(C(=O)C3=CC=C(C=C3)Cl)O2
Molecular Formula
C15H9ClO2
Molecular Weight
256.68
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-A; MAO-B
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
GFAP (GA-5 + ASTRO/789), Biotin conjugate, 0.1mg/mL
Adapter pack for 7ml tubes in Z207-A rotors, 2/pk.
ANKRD58 (SOWAHD) (NM_001105576) Human Recombinant Protein
