Tetrahydropapaveroline (hydrobromide)

Tetrahydropapaveroline (Norlaudanosoline) hydrobromide, an isoquinoline alkaloid, is a condensation product of dopamine and dopaldehyde. Tetrahydropapaveroline hydrobromide inhibits [3H]DA uptake with a Ki of 41 μM. Tetrahydropapaveroline hydrobromide can be used for the study of Parkinson's disease and/or alcohol addiction[1][2].

Product Specifications

CAS Number

[16659-88-4]

Product Name Alternative

Norlaudanosoline (hydrobromide)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.82

Smiles

OC1=CC=C(CC2NCCC3=CC(O)=C(C=C32)O)C=C1O.Br

Molecular Formula

C16H18BrNO4

Molecular Weight

368.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhu W, Mantione KJ, Shen L, Lee B, Stefano GB. Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: nicotine addiction. Cell Mol Neurobiol. 2006;26 (4-6) :1037-1045. |[2]Okada T, et al. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells. Neurosci Res. 1998 Jan;30 (1) :87-90.