2-Guanidinobezimidazole
2-Guanidinobezimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM to His-GFP-NLRP3. 2-Guanidinobezimidazole binds directly to the LRR domain of NLRP3, promoting inflammasome assembly and activation. 2-Guanidinobezimidazole promotes anti-tumor immunity, inhibits tumor growth, and overcome immune checkpoint blockade (ICB) resistance[1].
Product Specifications
CAS Number
5418-95-1
Product Name Alternative
2GBI
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
95.74
Smiles
N/C(N)=N/C1=NC2=CC=CC=C2N1
Molecular Formula
C8H9N5
Molecular Weight
175.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu X, et al. A small molecule directly targets NLRP3 to promote inflammasome activation and antitumor immunity. Cell Death Dis. 2025 Apr 4;16 (1) :252.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
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