PAMAM Dendrimer G0.0 amine (20% in methanol)

PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM) . At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5) . PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems[1][2][3][4].

Product Specifications

CAS Number

[155773-72-1]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Drug Intermediate

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(CCN(CCN(CCC(NCCN)=O)CCC(NCCN)=O)CCC(NCCN)=O)NCCN

Molecular Formula

C22H48N10O4

Molecular Weight

516.68

Precautions

H302, H315, H319, H335

References & Citations

[4]Xiao Y, et al. Surface characterization, modification chemistry, and separation performance of polyimide and polyamidoamine dendrimer composite films. Langmuir. 2004 Sep 14;20 (19) :8230-8.|[1]Heiden TC, et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol Appl Pharmacol. 2007 Nov 15;225 (1) :70-9.|[2]Förstner P, et al. Cationic PAMAM dendrimers as pore-blocking binary toxin inhibitors. Biomacromolecules. 2014 Jul 14;15 (7) :2461-74.|[3]Sohail I, et al. Polyamidoamine (PAMAM) dendrimers synthesis, characterization and adsorptive removal of nickel ions from aqueous solution[J]. Journal of Materials Research and Technology, 2020, 9 (1) : 498-506.