(+) -Medioresinol

(+) -Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+) -Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+) -Medioresinol induces intracellular ROS accumulation and mitochondrial-mediated apoptosis in Candida albicans. (+) -Medioresinol inhibits LPS (HY-D1056) -stimulated IL-12p40 production. (+) -Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+) -Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke[1][2][3][4][5].

Product Specifications

CAS Number

[40957-99-1]

UNSPSC

12352005

Target

Akt; Apoptosis; Bacterial; Fungal; Interleukin Related; MMP; mTOR; PGC-1α; PI3K; PPAR; Pyroptosis; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/plus-medioresinol.html

Purity

98.88

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(O)C(OC)=CC([C@]2([H])[C@]3([H])[C@@](CO2)([H])[C@](C4=CC(OC)=C(C=C4)O)([H])OC3)=C1

Molecular Formula

C21H24O7

Molecular Weight

388.41

References & Citations

[1] Ji Hong Hwang, et al. (+) -Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. Biochimie. 2012 Aug;94 (8) :1784-93.|[2]Ji Hong Hwang, et al. Synergistic antibacterial and antibiofilm effect between (+) -medioresinol and antibiotics in vitro. Appl Biochem Biotechnol. 2013 Aug;170 (8) :1934-41.|[3]Nhiem NX, et al. Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. J Nat Prod. 2013 Apr 26;76 (4) :495-502.|[4]Qin X, et al. Medioresinol from Eucommiae cortex improves myocardial infarction-induced heart failure through activation of the PI3K/AKT/mTOR pathway: A network analysis and experimental study. PLoS One. 2024 Sep 27;19 (9) :e0311143. |[5]Wang Y, et al. Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis. Pharmacol Res. 2021 Jul;169:105640.