Desethoxy Quetiapine (dihydrochloride)

Desethoxy Quetiapine dihydrochloride (Compound 28) is an antagonist for dopamine D2 receptor with an IC50 of 1330 nM. Desethoxy Quetiapine dihydrochloride antagonises Apomorphine (HY-12723) -induced climbing and swimming disruption in mouse models[1].

Product Specifications

CAS Number

[329218-14-6]

UNSPSC

12352005

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OCCN(CC1)CCN1C2=NC3=CC=CC=C3SC4=CC=CC=C42.Cl.Cl

Molecular Formula

C19H23Cl2N3OS

Molecular Weight

412.38

References & Citations

[1]Warawa EJ, et al., Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel. J Med Chem. 2001 Feb 1;44 (3) :372-89.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

D2 Receptor

Available Sizes

Curated Selection

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