Aβ aggregation-IN-1
Aβ aggregation-IN-1 (Compound 1b) is an amyloid-beta precursor protein inhibitor. Aβ aggregation-IN-1 inhibits amyloid-beta aggregation and disaggregation of fibrillogenesis with IC50 values of 3.92 and 7.19 M, respectively. Aβ aggregation-IN-1 also inhibits malondialdehyde formation, augments the intracellular reduced glutathione (GSH) levals and inhibits caspase 3 in neuronal cells[1].
Product Specifications
CAS Number
[352525-91-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC=C(/C=C/B(O)O)C=C1
Molecular Formula
C9H8BF3O2
Molecular Weight
215.97
Precautions
H315, H319, H335
References & Citations
[1]Jiménez-Aligaga K, et al. Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23 (2) :426-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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