Aβ aggregation-IN-1
Aβ aggregation-IN-1 (Compound 1b) is an amyloid-beta precursor protein inhibitor. Aβ aggregation-IN-1 inhibits amyloid-beta aggregation and disaggregation of fibrillogenesis with IC50 values of 3.92 and 7.19 M, respectively. Aβ aggregation-IN-1 also inhibits malondialdehyde formation, augments the intracellular reduced glutathione (GSH) levals and inhibits caspase 3 in neuronal cells[1].
Product Specifications
CAS Number
352525-91-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC=C(/C=C/B(O)O)C=C1
Molecular Formula
C9H8BF3O2
Molecular Weight
215.97
Precautions
H315, H319, H335
References & Citations
[1]Jiménez-Aligaga K, et al. Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23 (2) :426-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MP203042 200 Reactions
Clec4b2 Mouse qPCR Primer Pair (NM_001004159)
Sign In for Pricing
View Details 
BS.AB17.14005 10 mg/mL - 250 mL
Kanamycin (sulphate) 10 mg/ml, 250 ml
Sign In for Pricing
View Details 